Total synthesis of the antifungal depsipeptide petriellin A
Date
2011
Authors
Sleebs, M.
Scanlon, D.
Karas, J.
Maharani, R.
Hughes, A.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Journal of Organic Chemistry, 2011; 76(16):6686-6693
Statement of Responsibility
Marianne M. Sleebs, Denis Scanlon, John Karas, Rani Maharani, and Andrew B. Hughes
Conference Name
Abstract
We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase approach resulted in a protected linear precursor, which was cleaved from the solid support prior to cyclization and final deprotection. Use of advanced coupling agents for several hindered amides was a feature of the synthesis. The natural product was prepared in overall 5% yield.
School/Discipline
School of Chemistry and Physics
Dissertation Note
Provenance
Description
Publication Date (Web): July 8, 2011
Access Status
Rights
© 2011 American Chemical Society