Total synthesis of the antifungal depsipeptide petriellin A

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dc.contributor.authorSleebs, M.
dc.contributor.authorScanlon, D.
dc.contributor.authorKaras, J.
dc.contributor.authorMaharani, R.
dc.contributor.authorHughes, A.
dc.contributor.schoolSchool of Chemistry and Physics
dc.date.issued2011
dc.descriptionPublication Date (Web): July 8, 2011
dc.description.abstractWe report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase approach resulted in a protected linear precursor, which was cleaved from the solid support prior to cyclization and final deprotection. Use of advanced coupling agents for several hindered amides was a feature of the synthesis. The natural product was prepared in overall 5% yield.
dc.description.statementofresponsibilityMarianne M. Sleebs, Denis Scanlon, John Karas, Rani Maharani, and Andrew B. Hughes
dc.identifier.citationJournal of Organic Chemistry, 2011; 76(16):6686-6693
dc.identifier.doi10.1021/jo201017w
dc.identifier.issn0022-3263
dc.identifier.issn1520-6904
dc.identifier.urihttp://hdl.handle.net/2440/71355
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.rights© 2011 American Chemical Society
dc.source.urihttps://doi.org/10.1021/jo201017w
dc.subjectAmides
dc.subjectPeptides, Cyclic
dc.subjectDepsipeptides
dc.subjectAntifungal Agents
dc.subjectMolecular Structure
dc.subjectCyclization
dc.titleTotal synthesis of the antifungal depsipeptide petriellin A
dc.typeJournal article
pubs.publication-statusPublished

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