An amino acid N-derivatising group that can be coloured on demand
Date
2002
Authors
Abell, A.
Martyn, D.
May, B.
Nabbs, B.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry, 2002; 43(20):3673-3675
Statement of Responsibility
Andrew D. Abell, Derek C. Martyn, Barnaby C. H. May and Brent K. Nabbs
Conference Name
Abstract
A method is presented whereby an amino acid is reacted with 5-formyl-1H-pyrrole-2-carboxylic acid to give an N-derivatised tag that has a latent ability to be coloured. A characteristic red pyrrolizin-3-one (coloured tag) is then revealed on treatment with hydrocinnamoyl chloride. This sequence has been carried out on amino acids in solution, and on solid phase, and also on dipeptides. A method is presented whereby an amino acid is reacted with 5-formyl-1H-pyrrole-2-carboxylic acid to give an N-derivatised tag that has a latent ability to be coloured.