An amino acid N-derivatising group that can be coloured on demand

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dc.contributor.authorAbell, A.
dc.contributor.authorMartyn, D.
dc.contributor.authorMay, B.
dc.contributor.authorNabbs, B.
dc.date.issued2002
dc.description.abstractA method is presented whereby an amino acid is reacted with 5-formyl-1H-pyrrole-2-carboxylic acid to give an N-derivatised tag that has a latent ability to be coloured. A characteristic red pyrrolizin-3-one (coloured tag) is then revealed on treatment with hydrocinnamoyl chloride. This sequence has been carried out on amino acids in solution, and on solid phase, and also on dipeptides. A method is presented whereby an amino acid is reacted with 5-formyl-1H-pyrrole-2-carboxylic acid to give an N-derivatised tag that has a latent ability to be coloured.
dc.description.statementofresponsibilityAndrew D. Abell, Derek C. Martyn, Barnaby C. H. May and Brent K. Nabbs
dc.description.urihttp://www.sciencedirect.com/science/journal/00404039
dc.format.extent158746 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citationTetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry, 2002; 43(20):3673-3675
dc.identifier.doi10.1016/S0040-4039(02)00625-1
dc.identifier.issn0040-4039
dc.identifier.orcidAbell, A. [0000-0002-0604-2629]
dc.identifier.urihttp://hdl.handle.net/2440/36372
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.source.urihttps://doi.org/10.1016/s0040-4039(02)00625-1
dc.titleAn amino acid N-derivatising group that can be coloured on demand
dc.typeJournal article
pubs.publication-statusPublished

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