Harnessing the chemokine system to home CAR-T cells into solid tumors
Date
2022
Authors
Foeng, J.
Comerford, I.
McColl, S.R.
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Journal article
Citation
Cell Reports Medicine, 2022; 3(3):100543-1-100543-15
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Jade Foeng, Iain Comerford, and Shaun R. McColl
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Abstract
CAR-T cell therapy has been heralded as a breakthrough in the field of immunotherapy, but to date, this suc- cess has been limited to hematological malignancies. By harnessing the chemokine system and taking into consideration the chemokine expression profile in the tumor microenvironment, CAR-T cells may be homed into tumors to facilitate direct tumor cell cytolysis and overcome a major hurdle in generating effective CAR-T cell responses to solid cancers.
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© 2022 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).