Harnessing the chemokine system to home CAR-T cells into solid tumors

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dc.contributor.authorFoeng, J.
dc.contributor.authorComerford, I.
dc.contributor.authorMcColl, S.R.
dc.date.issued2022
dc.description.abstractCAR-T cell therapy has been heralded as a breakthrough in the field of immunotherapy, but to date, this suc- cess has been limited to hematological malignancies. By harnessing the chemokine system and taking into consideration the chemokine expression profile in the tumor microenvironment, CAR-T cells may be homed into tumors to facilitate direct tumor cell cytolysis and overcome a major hurdle in generating effective CAR-T cell responses to solid cancers.
dc.description.statementofresponsibilityJade Foeng, Iain Comerford, and Shaun R. McColl
dc.identifier.citationCell Reports Medicine, 2022; 3(3):100543-1-100543-15
dc.identifier.doi10.1016/j.xcrm.2022.100543
dc.identifier.issn2666-3791
dc.identifier.issn2666-3791
dc.identifier.orcidMcColl, S.R. [0000-0003-0949-4660]
dc.identifier.urihttps://hdl.handle.net/2440/135149
dc.language.isoen
dc.publisherElsevier BV
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1030247
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1105312
dc.rights© 2022 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.source.urihttps://doi.org/10.1016/j.xcrm.2022.100543
dc.subjectT-Lymphocytes
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectReceptors, Antigen, T-Cell
dc.subjectChemokines
dc.subjectImmunotherapy, Adoptive
dc.subjectTumor Microenvironment
dc.subject.meshT-Lymphocytes
dc.subject.meshHumans
dc.subject.meshNeoplasms
dc.subject.meshReceptors, Antigen, T-Cell
dc.subject.meshChemokines
dc.subject.meshImmunotherapy, Adoptive
dc.subject.meshTumor Microenvironment
dc.titleHarnessing the chemokine system to home CAR-T cells into solid tumors
dc.typeJournal article
pubs.publication-statusPublished

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