Genome-wide association study of co-occurring anxiety in major depression

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dc.contributor.authorSchosser, A.
dc.contributor.authorButler, A.
dc.contributor.authorUher, R.
dc.contributor.authorNg, M.
dc.contributor.authorCohen-Woods, S.
dc.contributor.authorCraddock, N.
dc.contributor.authorOwen, M.
dc.contributor.authorKorszun, A.
dc.contributor.authorGill, M.
dc.contributor.authorRice, J.
dc.contributor.authorHauser, J.
dc.contributor.authorHenigsberg, N.
dc.contributor.authorMaier, W.
dc.contributor.authorMors, O.
dc.contributor.authorPlacentino, A.
dc.contributor.authorRietschel, M.
dc.contributor.authorSouery, D.
dc.contributor.authorPreisig, M.
dc.contributor.authorCraig, I.
dc.contributor.authorFarmer, A.
dc.contributor.authoret al.
dc.date.issued2013
dc.description.abstractOBJECTIVES: Co-morbidity between depression and anxiety disorders is common. In this study we define a quantitative measure of anxiety by summating four anxiety items from the SCAN interview in a large collection of major depression (MDD) cases to identify genes contributing to this complex phenotype. METHODS: A total of 1522 MDD cases dichotomised according to those with at least one anxiety item scored (n = 1080) and those without anxiety (n = 442) were analysed, and also compared to 1588 healthy controls at a genome-wide level, to identify genes that may contribute to anxiety in MDD. RESULTS: For the quantitative trait, suggestive evidence of association was detected for two SNPs, and for the dichotomous anxiety present/absent ratings for three SNPs at genome-wide level. In the genome-wide analysis of MDD cases with co-morbid anxiety and healthy controls, two SNPs attained P values of < 5 × 10⁻⁶. Analysing candidate genes, P values ≤ 0.0005 were found with three SNPs for the quantitative trait and three SNPs for the dichotomous trait. CONCLUSIONS: This study provides an initial genome-wide assessment of possible genetic contribution to anxiety in MDD. Although suggestive evidence of association was found for several SNPs, our findings suggest that there are no common variants strongly associated with anxious depression.
dc.description.statementofresponsibilityAlexandra Schosser, Amy W. Butler, Rudolf Uher, Mandy Y. Ng, Sarah Cohen-Woods, Nick Craddock, Mike J. Owen, Ania Korszun, Michael Gill, John Rice, Neven Henigsberg, Wolfgang Maier, Ole Mors, Anna Placentino, Marcella Rietsche, Daniel Souery, Martin Preisig, Ian W. Craig, Anne E. Farmer, Cathryn M. Lewis & Peter McGuffin
dc.identifier.citationWorld Journal of Biological Psychiatry, 2013; 14(8):611-621
dc.identifier.doi10.3109/15622975.2013.782107
dc.identifier.issn1562-2975
dc.identifier.issn1814-1412
dc.identifier.orcidCohen-Woods, S. [0000-0003-2199-6129]
dc.identifier.urihttp://hdl.handle.net/2440/93361
dc.language.isoen
dc.publisherInforma Healthcare
dc.rights© 2013 Informa Healthcare
dc.source.urihttps://doi.org/10.3109/15622975.2013.782107
dc.subjectGWAS
dc.subjectanxiety
dc.subjectMDD
dc.subjectassociation
dc.subjectdepression
dc.titleGenome-wide association study of co-occurring anxiety in major depression
dc.typeJournal article
pubs.publication-statusPublished

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