Total synthesis of variolin B
Date
2001
Authors
Anderson, Regan James
Morris, Jonathan Charles
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Tetrahedron Letters, 2001; 42(49):8697-8699
Statement of Responsibility
Regan J. Anderson and Jonathan C. Morris
Conference Name
Abstract
The total synthesis of the marine alkaloid variolin B has been achieved in eight steps, starting from commercially available 4-chloro-2-methylthiopyrimidine. The key reaction involves the tandem deoxygenation and cyclization of a triarylmethanol using a combination of triethylsilane and trifluoroacetic acid.
School/Discipline
School of Chemistry and Physics : Chemistry