A Guide to Measuring and Interpreting Omega-3 (n-3) Fatty Acid Status in Relation to Health

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dc.contributor.authorGibson, R.A.
dc.contributor.authorSimmonds, L.A.
dc.contributor.authorLiu, G.
dc.contributor.authorCoates, P.
dc.contributor.authorLam, K.
dc.contributor.authorRanieri, E.
dc.contributor.authorMas, E.
dc.contributor.authorMakrides, M.
dc.date.issued2024
dc.description.abstractDietary fats can play a role in life-long health outcomes. The role of polyunsaturated fatty acids (PUFA) in health and disease has been a keen focus of researchers for over 50 years. Recently the focus of this research has turned to the beneficial role of the omega-3 (n-3) PUFA on health outcomes including heart disease and the prevention of preterm birth. From the standpoint of clinical practice, there has been a call for reliable screening tests that can predict risk. Two tests, both involving the measurement of n-3 PUFA in blood or its fractions, have become prominent, namely, the ‘omega-3 index’ as a predictor of cardiovascular disease risk and the ‘total n-3’ pregnancy test as a predictor of risk of premature birth. We provide an overview for pathologists, clinicians and nutritionists of the methodology and terminology related to the n-3 biomarkers to aid their interpretation of proposed cut-point values for health risk.
dc.description.statementofresponsibilityRobert A. Gibson, Lucy A. Simmonds, Ge Liu, Penelope Coates, Khoa Lam, Enzo Ranieri, Emilie Mas, Maria Makrides
dc.identifier.citationClinical Biochemist Reviews, 2024; 44(1):29-36
dc.identifier.doi10.33176/AACB-22-00007
dc.identifier.issn0159-8090
dc.identifier.issn1838-0212
dc.identifier.orcidGibson, R.A. [0000-0002-8750-525X]
dc.identifier.orcidMas, E. [0000-0003-2848-9613]
dc.identifier.orcidMakrides, M. [0000-0003-3832-541X]
dc.identifier.urihttps://hdl.handle.net/2440/148025
dc.language.isoen
dc.publisherAustralasian Association of Clinical Biochemists
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1135155
dc.rightsCopyright status unknown
dc.source.urihttps://doi.org/10.33176/aacb-22-00007
dc.subjectOmega-3; Fatty acids; Dietary fats; Screening; Risk prediction
dc.titleA Guide to Measuring and Interpreting Omega-3 (n-3) Fatty Acid Status in Relation to Health
dc.typeJournal article
pubs.publication-statusPublished

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