Lipid liquid crystal nanostructures to enhance the delivery and efficacy of antimicrobials against bacterial biofilms /
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(Published version)
Date
2021
Authors
Thorn, Chelsea Renee
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Type:
thesis
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Abstract
Bacterial biofilms account for up to 80% of all infections, and currently, there are no effective treatments available. Strategies that overcome biofilm barriers and target the bacterial site are urgently required. Despite the promise of lipid nanoparticles, clinical translation has not been successful. This thesis investigated and developed lipid liquid crystal nanoparticles (LCNPs) for the first time to improve the eradication of bacterial biofilms. Three significant mechanisms of LCNPs are realised: (1) bacterial-responsive release, (2) biomimicry, enhancing antimicrobial efficacy, and (3) co-delivery and protection of biofilm dispersing enzymes. LCNPs are deemed a powerful formulation strategy for an array of antimicrobials, showing potential to revolutionise therapies, particularly against P. aeruginosa biofilm infections in cystic fibrosis and non-healing wounds.
School/Discipline
University of South Australia. UniSA Clinical and Health Sciences.
UniSA Clinical and Health Sciences
UniSA Clinical and Health Sciences
Dissertation Note
Thesis (PhD(Pharmaceutical Science))--University of South Australia, 2021.
Provenance
Copyright 2021 Chelsea Renee Thorn.
Description
1 ethesis (xviii, 355 pages) :
colour illustrations.
Includes bibliographical references (pages 313-337)
colour illustrations.
Includes bibliographical references (pages 313-337)
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506 0#$fstar $2Unrestricted online access