Current studentsExisting staffContact us
 

Lipid liquid crystal nanostructures to enhance the delivery and efficacy of antimicrobials against bacterial biofilms /

Simple item page
dc.contributor.authorThorn, Chelsea Renee
dc.contributor.schoolUniversity of South Australia. UniSA Clinical and Health Sciences.
dc.contributor.schoolUniSA Clinical and Health Sciences
dc.date.issued2021
dc.description1 ethesis (xviii, 355 pages) :
dc.descriptioncolour illustrations.
dc.descriptionIncludes bibliographical references (pages 313-337)
dc.description.abstractBacterial biofilms account for up to 80% of all infections, and currently, there are no effective treatments available. Strategies that overcome biofilm barriers and target the bacterial site are urgently required. Despite the promise of lipid nanoparticles, clinical translation has not been successful. This thesis investigated and developed lipid liquid crystal nanoparticles (LCNPs) for the first time to improve the eradication of bacterial biofilms. Three significant mechanisms of LCNPs are realised: (1) bacterial-responsive release, (2) biomimicry, enhancing antimicrobial efficacy, and (3) co-delivery and protection of biofilm dispersing enzymes. LCNPs are deemed a powerful formulation strategy for an array of antimicrobials, showing potential to revolutionise therapies, particularly against P. aeruginosa biofilm infections in cystic fibrosis and non-healing wounds.
dc.description.dissertationThesis (PhD(Pharmaceutical Science))--University of South Australia, 2021.
dc.identifier.urihttps://hdl.handle.net/11541.2/26280
dc.language.isoen
dc.provenanceCopyright 2021 Chelsea Renee Thorn.
dc.subjectantimicrobials,;drug delivery;lipid nanoparticles;biofilms
dc.subject.lcshAntibacterial agents.
dc.subject.lcshBacterial diseases
dc.subject.lcshBiofilms.
dc.subject.lcshNanoparticles.
dc.titleLipid liquid crystal nanostructures to enhance the delivery and efficacy of antimicrobials against bacterial biofilms /
dc.typethesis
dcterms.accessRights506 0#$fstar $2Unrestricted online access
ror.fileinfo12236516290001831 13236516280001831 Thorn, Chelsea - Thesis
ror.mmsid9916584251601831

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Thorn, Chelsea - Thesis_Redacted.pdf
Size:
17.56 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections