Impact of microbial genome completeness on metagenomic functional inference

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dc.contributor.authorEisenhofer, R.
dc.contributor.authorOdriozola, I.
dc.contributor.authorAlberdi, A.
dc.date.issued2023
dc.description.abstractInferring the functional capabilities of bacteria from metagenome-assembled genomes (MAGs) is becoming a central process in microbiology. Here we show that the completeness of genomes has a significant impact on the recovered functional signal, spanning all domains of metabolic functions. We identify factors that affect this relationship between genome completeness and function fullness, and provide baseline knowledge to guide efforts to correct for this overlooked bias in metagenomic functional inference.
dc.description.statementofresponsibilityRaphael Eisenhofer, IƱaki Odriozola, and Antton Alberdi
dc.identifier.citationISME Communications: New Developments in Microbial Ecology, 2023; 3(1):12-1-12-5
dc.identifier.doi10.1038/s43705-023-00221-z
dc.identifier.issn2730-6151
dc.identifier.issn2730-6151
dc.identifier.urihttps://hdl.handle.net/2440/146585
dc.language.isoen
dc.publisherOxford University Press
dc.rightsĀ© The Author(s) 2023. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the articleā€™s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the articleā€™s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.source.urihttp://dx.doi.org/10.1038/s43705-023-00221-z
dc.subjectbacteria; metagenome-assembled genomes (MAGs); functionality
dc.titleImpact of microbial genome completeness on metagenomic functional inference
dc.typeJournal article
pubs.publication-statusPublished

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