Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes

Obando, D.; Pantarat, N.; Handke, R.; Koda, Y.; Widmer, F.; Djordjevic, J.; Ellis, D.; Sorrell, T.; Jolliffe, K.

doi:10.1016/j.bmc.2009.07.037

Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes

Date

2009

Authors

Obando, D.

Pantarat, N.

Handke, R.

Koda, Y.

Widmer, F.

Djordjevic, J.

Ellis, D.

Sorrell, T.

Jolliffe, K.

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Journal article

Citation

Bioorganic and Medicinal Chemistry, 2009; 17(17):6329-6339

Statement of Responsibility

Daniel Obando, Namfon Pantarat, Rosemary Handke, Yasuko Koda, Fred Widmer, Julianne T. Djordjevic, David H. Ellis, Tania C. Sorrell and Katrina A. Jolliffe

DOI

10.1016/j.bmc.2009.07.037

Abstract

A series of bis(alkylpyridinium)alkanes with a twelve carbon spacer between the positive charges was synthesised and their antifungal activity has been investigated. Compounds with 2-pentyl, 4-pentyl, 4-hexyl, 4-octyl, 4-propylbenzene, 3,4-dipentyl, 4-(5′-nonyl) and 3-methyl,4-pentyl head groups were the most potent antifungal agents with MICs in the range of 1.4–2.7 μM against reference strains of both Cryptococcus neoformans and Candida albicans.

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Available online 23 July 2009.

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https://doi.org/10.1016/j.bmc.2009.07.037

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http://hdl.handle.net/2440/51191

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Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes

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