Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes

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dc.contributor.authorObando, D.
dc.contributor.authorPantarat, N.
dc.contributor.authorHandke, R.
dc.contributor.authorKoda, Y.
dc.contributor.authorWidmer, F.
dc.contributor.authorDjordjevic, J.
dc.contributor.authorEllis, D.
dc.contributor.authorSorrell, T.
dc.contributor.authorJolliffe, K.
dc.date.issued2009
dc.descriptionAvailable online 23 July 2009.
dc.description.abstractA series of bis(alkylpyridinium)alkanes with a twelve carbon spacer between the positive charges was synthesised and their antifungal activity has been investigated. Compounds with 2-pentyl, 4-pentyl, 4-hexyl, 4-octyl, 4-propylbenzene, 3,4-dipentyl, 4-(5′-nonyl) and 3-methyl,4-pentyl head groups were the most potent antifungal agents with MICs in the range of 1.4–2.7 μM against reference strains of both Cryptococcus neoformans and Candida albicans.
dc.description.statementofresponsibilityDaniel Obando, Namfon Pantarat, Rosemary Handke, Yasuko Koda, Fred Widmer, Julianne T. Djordjevic, David H. Ellis, Tania C. Sorrell and Katrina A. Jolliffe
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/129/description#description
dc.identifier.citationBioorganic and Medicinal Chemistry, 2009; 17(17):6329-6339
dc.identifier.doi10.1016/j.bmc.2009.07.037
dc.identifier.issn0968-0896
dc.identifier.issn1464-3391
dc.identifier.orcidEllis, D. [0000-0002-7283-4667]
dc.identifier.urihttp://hdl.handle.net/2440/51191
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.rightsCopyright © 2009 Elsevier Ltd. All rights reserved
dc.source.urihttps://doi.org/10.1016/j.bmc.2009.07.037
dc.subjectBispyridinium
dc.subjectAntifungal activity
dc.subjectHaemolytic activity
dc.subjectFungal phospholipase B
dc.titleSynthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes
dc.typeJournal article
pubs.publication-statusPublished

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