The Impact of Lactobacillus reuteri on Oral and Systemic Health: A Comprehensive Review of Recent Research
Date
2025
Authors
Liu, Z.
Cao, Q.
Wang, W.
Wang, B.
Yang, Y.
Xian, C.J.
Li, T.
Zhai, Y.
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Journal article
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Microorganisms, 2025; 13(1)
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Abstract
Oral diseases, particularly dental caries and periodontal disease, pose significant global health challenges. The imbalance of the oral microbiota plays a key role in the occurrence of these diseases, prompting researchers to seek new strategies to restore oral ecological balance. <i>Lactobacillus reuteri</i> is a Gram-positive rod-shaped bacterium that exists in various body parts of humans, including the gastrointestinal tract, urinary tract, skin, and so on. This species has a potentially positive impact on oral health and plays an important role in maintaining systemic health. Recent studies have explored the application of <i>Lactobacillus reuteri</i> in the prevention and treatment of oral diseases, and its impact on systemic health has also been preliminarily revealed. The current review summarizes the role of <i>Lactobacillus reuteri</i> in oral health and systemic health and outlines its potential applications in the future. <i>Lactobacillus reuteri</i> has shown promising prospects in treating non-communicable biofilm-dependent oral diseases, but its mechanism of action and efficacy still need further research. In addition, <i>Lactobacillus reuteri</i> has also displayed some potential benefits in promoting overall health. Future research should focus on revealing the specific pathways of action of <i>Lactobacillus reuteri</i>, screening for the most beneficial strains, determining the most effective drug delivery strategies, developing oral and systemic health products based on <i>Lactobacillus reuteri</i>, and ensuring their safety in clinical applications.
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Copyright 2024 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. (https://creativecommons.org/licenses/by/4.0/)