The Impact of Lactobacillus reuteri on Oral and Systemic Health: A Comprehensive Review of Recent Research

dc.contributor.authorLiu, Z.
dc.contributor.authorCao, Q.
dc.contributor.authorWang, W.
dc.contributor.authorWang, B.
dc.contributor.authorYang, Y.
dc.contributor.authorXian, C.J.
dc.contributor.authorLi, T.
dc.contributor.authorZhai, Y.
dc.date.issued2025
dc.description.abstractOral diseases, particularly dental caries and periodontal disease, pose significant global health challenges. The imbalance of the oral microbiota plays a key role in the occurrence of these diseases, prompting researchers to seek new strategies to restore oral ecological balance. <i>Lactobacillus reuteri</i> is a Gram-positive rod-shaped bacterium that exists in various body parts of humans, including the gastrointestinal tract, urinary tract, skin, and so on. This species has a potentially positive impact on oral health and plays an important role in maintaining systemic health. Recent studies have explored the application of <i>Lactobacillus reuteri</i> in the prevention and treatment of oral diseases, and its impact on systemic health has also been preliminarily revealed. The current review summarizes the role of <i>Lactobacillus reuteri</i> in oral health and systemic health and outlines its potential applications in the future. <i>Lactobacillus reuteri</i> has shown promising prospects in treating non-communicable biofilm-dependent oral diseases, but its mechanism of action and efficacy still need further research. In addition, <i>Lactobacillus reuteri</i> has also displayed some potential benefits in promoting overall health. Future research should focus on revealing the specific pathways of action of <i>Lactobacillus reuteri</i>, screening for the most beneficial strains, determining the most effective drug delivery strategies, developing oral and systemic health products based on <i>Lactobacillus reuteri</i>, and ensuring their safety in clinical applications.
dc.identifier.citationMicroorganisms, 2025; 13(1)
dc.identifier.doi10.3390/microorganisms13010045
dc.identifier.issn2076-2607
dc.identifier.issn2076-2607
dc.identifier.orcidXian, C.J. [0000-0002-8467-2845]
dc.identifier.urihttps://hdl.handle.net/11541.2/41596
dc.language.isoen
dc.publisherMDPI
dc.relation.fundingFoundation of Science and Technology Department of Henan Province of China
dc.relation.fundingNatural Science Foundation of Education Department of Henan Province 25A320004
dc.relation.fundingFoundation of Science and Technology Department of Luoyang City of Henan Province 2101065A
dc.relation.fundingFoundation of Science and Technology Department of Kaifeng City of Henan Province 2203015
dc.relation.fundingFoundation of Key Lab of Medical Molecular Cell Biology of Shanxi Province and Shanxi University MMCB-OP-2023-03
dc.relation.fundingFoundation for Young Scholar in School of Stomatology of Henan University HUSSYS2024005
dc.rightsCopyright 2024 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. (https://creativecommons.org/licenses/by/4.0/)
dc.source.urihttps://doi.org/10.3390/microorganisms13010045
dc.subjectLactobacillus reuteri
dc.subjectdental caries
dc.subjectgastrointestinal diseases
dc.subjectmicrobiome
dc.subjectoral mucosal diseases
dc.subjectperiodontal diseases
dc.titleThe Impact of Lactobacillus reuteri on Oral and Systemic Health: A Comprehensive Review of Recent Research
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12298045380001831 13298045370001831 Open Access Published Version
ror.mmsid9916939742201831

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