Artemisinin resistance and the unique selection pressure of a short-acting antimalarial

Khoury, D.S.; Cao, P.; Zaloumis, S.G.; Davenport, M.P.; The Interdisciplinary Approaches to Malaria Consortium,

doi:10.1016/j.pt.2020.07.004

Artemisinin resistance and the unique selection pressure of a short-acting antimalarial

Date

2020

Authors

Khoury, D.S.

Cao, P.

Zaloumis, S.G.

Davenport, M.P.

The Interdisciplinary Approaches to Malaria Consortium,

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Journal article

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Trends in Parasitology, 2020; 36(11):884-887

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David S. Khoury, Pengxing Cao, Sophie G. Zaloumis, Miles P. Davenport, Danny Wilson, The Interdisciplinary Approaches to Malaria Consortium (Danny Wilson part of the Consortium)

DOI

10.1016/j.pt.2020.07.004

Abstract

Resistance to the artemisinin derivatives, our most effective antimalarial drugs, has not manifest as a classical resistance phenotype in which parasites can tolerate higher drug concentrations. Instead, resistant parasites have an altered maturation. We hypothesize that the short half-life of artemisinin concentrations is an unanticipated driver of this novel resistance phenotype.

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https://doi.org/10.1016/j.pt.2020.07.004

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https://hdl.handle.net/2440/134063

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Artemisinin resistance and the unique selection pressure of a short-acting antimalarial

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