Artemisinin resistance and the unique selection pressure of a short-acting antimalarial

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dc.contributor.authorKhoury, D.S.
dc.contributor.authorCao, P.
dc.contributor.authorZaloumis, S.G.
dc.contributor.authorDavenport, M.P.
dc.contributor.authorThe Interdisciplinary Approaches to Malaria Consortium,
dc.date.issued2020
dc.description.abstractResistance to the artemisinin derivatives, our most effective antimalarial drugs, has not manifest as a classical resistance phenotype in which parasites can tolerate higher drug concentrations. Instead, resistant parasites have an altered maturation. We hypothesize that the short half-life of artemisinin concentrations is an unanticipated driver of this novel resistance phenotype.
dc.description.statementofresponsibilityDavid S. Khoury, Pengxing Cao, Sophie G. Zaloumis, Miles P. Davenport, Danny Wilson, The Interdisciplinary Approaches to Malaria Consortium (Danny Wilson part of the Consortium)
dc.identifier.citationTrends in Parasitology, 2020; 36(11):884-887
dc.identifier.doi10.1016/j.pt.2020.07.004
dc.identifier.issn0169-4758
dc.identifier.issn1471-5007
dc.identifier.urihttps://hdl.handle.net/2440/134063
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/arc/DP120100064
dc.relation.granthttp://purl.org/au-research/grants/arc/DP180103875
dc.relation.granthttp://purl.org/au-research/grants/arc/DP170103076
dc.relation.granthttp://purl.org/au-research/grants/arc/DE170100785
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1082022
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1141921
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1080001
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1173027
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1100394
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1104975
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1134989
dc.rights© 2020 Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.pt.2020.07.004
dc.subjectMalaria; drug resistance; artemisinin; selection pressure
dc.subject.meshAnimals
dc.subject.meshHumans
dc.subject.meshPlasmodium
dc.subject.meshArtemisinins
dc.subject.meshAntimalarials
dc.subject.meshInhibitory Concentration 50
dc.subject.meshDrug Resistance
dc.subject.meshSelection, Genetic
dc.titleArtemisinin resistance and the unique selection pressure of a short-acting antimalarial
dc.typeJournal article
pubs.publication-statusPublished

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