School of Chemistry and Physics
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Item Metadata only 1,2,3-triazoles in peptidomimetic chemistry(Wiley-V C H Verlag GMBH, 2011) Pedersen, D.; Abell, A.The ability to synthesise small peptidomimetics that mimic the secondary structure of proteins is an ever expanding area of research directed at sourcing new medicinal agents and biological probes. A significant current challenge is to mimic protein epitopes under physiological conditions using small peptidomimetics that are easy to prepare. The copper- and ruthenium-catalysed Huisgen cycloaddition reactions provide such a general synthetic method, with the resulting 1,2,3-triazoles being good peptide bond mimics. The ability to prepare both 1,4- and 1,5-substituted 1,2,3-triazoles under these chemically benign conditions provides both “linear” and “bent” peptidomimetics. Examples of the use of 1,2,3-triazoles to define the geometry and properties of a peptidomimetic abound. This review highlights such successes but also describes a number of failures in order to guide and inspire future efforts of chemists in this area.Item Metadata only 1,2,3-Triazolyl amino acids as AMPA receptor ligands(Pergamon-Elsevier Science Ltd, 2010) Stanley, N.; Pedersen, D.; Nielsen, B.; Kvist, T.; Mathiesen, J.; Brauner-Osborne, H.; Taylor, D.; Abell, A.The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.Item Metadata only 1,2-dioxines as masked cis γ-hydroxy enones and their versatility in the synthesis of highly substituted γ-lactones(Amer Chemical Soc, 2002) Greatrex, B.; Kimber, M.; Taylor, D.; Fallon, G.; Tiekink, E.Addition of highly stabilized ester nucleophiles to 1,2-dioxines affords good to high yields of γ-lactones with high diastereoselectivity. Heterolytic or homolytic cleavage of the 1,2-dioxines under appropriate conditions generates the key reactive cis γ-hydroxy enones, which ultimately afford the observed γ-lactones. Diastereoselectivity is installed as a result of anti 1,4-addition by the ester enolate to the cis enones followed by intramolecular cyclization. The reaction is tolerant of a range of substitution patterns on the 1,2-dioxine while a broad range of esters are also accommodated. In addition to the synthesis of racemic γ-lactones, highly enantioenriched γ-lactones can also be synthesized when chiral cobalt(II) catalysts are employed for the initial homolytic ring-opening of the 1,2-dioxine.Item Metadata only 1,2-dioxines containing tethered hydroxyl functionality as convenient precursors for pyran syntheses(Amer Chemical Soc, 2005) Avery, T.; Caiazza, D.; Culbert, J.; Taylor, D.; Tiekink, E.A new method for the construction of tetrahydropyrans derived from readily available 1,2-dioxines containing a tethered hydroxyl moiety is described. The reaction proceeds via a base-catalyzed rearrangement of the 1,2-dioxines to either the isomeric cis or trans -hydroxy enones followed by intramolecular oxa-Michael addition of the tethered hydroxyl group.Item Metadata only (1,3-Benzo[d]dioxol-5-yl)(2-pyridyl)methyl cyanide(International Union of Crystallography, 2001) Duthie, Andrew; Scammells, Peter J.; Katsifis, Andrew; Tiekink, Edward Richard Tom; School of Chemistry and PhysicsIn the title compound, C₁₄H₁₀N₂O₂, the dihedral angle formed between the substituted pyridine ring and 1,3-benzodioxole group is 67.73 (6)°. The crystal features chains of molecules held together by alternating π⋯π and C—H⋯π interactions.Item Metadata only 1,3-Bis[(trimethylsilylmethyl)dichlorostannyl]propane,[(Me₃SiCH₂)Cl₂Sn]₂(CH₂)₃)(John Wiley & Sons, 2003) Dakternieks, Dainis; Kuan, Fong Sheen; Duthie, Andrew; Tiekink, Edward Richard Tom; School of Chemistry and PhysicsItem Metadata only 1,4-bis[(phenyldichlorostannyl)ethyl]benzene, p-(Cl2PhSnCH2CH2)2C6H4(John Wiley & Sons Ltd, 2003) Dakternieks, Dainis; Duthie, Andrew; Tiekink, Edward Richard Tom; School of Chemistry and PhysicsItem Metadata only 1,4-Bis[bis(trimethylsilyl)methyl- dichlorostannylmethyldimethylsilyl]benzene, p-{[(Me3Si)2CH]Sn(Cl)2CH2SiMe2}2C6H4(John Wiley & Sons Ltd, 2003) Dakternieks, Dainis; Zobel, Bernhard; Tiekink, Edward Richard Tom; School of Chemistry and PhysicsItem Metadata only 1,4-Diethynyl-2,5-dimethoxybenzene at ca 150 K(Blackwell Munksgaard, 2004) Bruce, M.; Head, N.; Skelton, B.; White, A.The principal determinants of packing in crystals of the title compound, C12H10O2, which has crystallographically imposed inversion symmetry, are interactions between the alkyne H atoms and the methoxy O atoms [HO = 2.39 (1) Å].Item Metadata only 1-+ exotic on the lattice with FLIC fermions(Few-body problems in physics, World Scientific Publishing Co. Pte. Ltd, 2007) Hedditch, J.; Lasscock, B.; Leinweber, D.; Williams, A.; Kamleh, W.; Zanotti, J.; Asia-Pacific Conference on Few-Body Problems in Physics (3rd : 2005 : Nakhon Ratchasima; Thailand); Yan, Y.; Kobdai, C.; Suebka, P.Item Metadata only 1-Bromoethene-1-sulfonyl fluoride (BESF) is another good connective hub for SuFEx click chemistry(Royal Society of Chemistry (RSC), 2018) Smedley, C.J.; Giel, M.C.; Molino, A.; Barrow, A.S.; Wilson, D.J.D.; Moses, J.E.We demonstrate 1,2-dibromoethane-1-sulfonyl fluoride (DESF) as a bench-stable and readily accessible precursor to the robust SuFEx connector, 1-bromoethene-1-sulfonyl fluoride (BESF). The in situ generation of BESF from DESF opens up several new reaction profiles, including application in the syntheses of unprecedented 3-substituted isoxazole-5-sulfonyl fluorides, 1-substituted-1H1,2,3-triazole-4-sulfonyl fluorides, 2-amino-1-bromoethane-1-sulfonyl fluorides and 4-bromo-b-sultams in good to excellent yields. These new modules comprise a pendant sulfonyl fluoride handle, which further undergoes facile and selective SuFEx reactions with a selection of aryl silyl ethers to generate stable and useful sulfonate connections.Item Metadata only 1.23 Ga mafic dykes in the North China Craton and their implications for the reconstruction of the Columbia supercontinent(Elsevier, 2015) Wang, W.; Liu, S.; Santosh, M.; Zhang, L.; Bai, X.; Zhao, Y.; Zhang, S.; Guo, R.Abstract not availableItem Metadata only 10W Injection-Locked CW Nd:YAG laser(2004) Hosken, D.; Mudge, D.; Veitch, P.; Munch, J.; LIGO Scientific Collaboration Meeting (2004 : Livingston, Louisiana)Item Metadata only 10W Nd:YAG laser for gravitational wave interferometry(2005) Hosken, D.; Mudge, D.; Veitch, P.; Munch, J.; Australasian Conference on Optics, Lasers and Spectroscopy (7th : 2005 : Rotorua, New Zealand)We shall describe the development and characterisation of an injection-locked 10W Nd:YAG laser. The laser is compact and reliable, and has low intensity and frequency noise.Item Open Access 10W Nd:YAG Laser for TAMA300(2005) Hosken, D.; Mudge, D.; Veitch, P.; Munch, J.; Takeno, K.; Edoardo Amaldi Conference on Gravitational Waves (6th : 2005: Okinawa, Japan)Item Metadata only 10W, Single Frequency, CW Nd:YAG Laser(Australian National University, 2005) Hosken, D.; Mudge, D.; Veitch, P.; Australian Institute of Physics Congress (16th : 2005 : Canberra, A.C.T.)We describe the development and characterisation of a 10W cw Nd:YAG travelling-wave laser[1] that is injectionlocked to produce a low noise, single frequency, diffraction limited TEM00 output[2,3]. The 10W slave laser uses the side pumped, top and bottom cooled, coplanar folded zigzag slab (CPFS) architecture[4] and has been optimised for portability and reliability. This laser is used at the high power test facility of the Australian Consortium for Interferometric Gravitational Astronomy (ACIGA), with another version to be installed on the Japanese TAMA long-baseline gravitational wave interferometer. We shall report on laser performance including amplitude and frequency stability. [1] D.J. Hosken, D. Mudge, C. Hollitt, K. Takeno, P.J. Veitch, M.W. Hamilton and J. Munch, Prog. Theor. Phys. Suppl. 151, 216, 2003. [2] D.J. Ottaway, P.J. Veitch, M.W. Hamilton, C. Hollitt, D. Mudge and J. Munch, IEEE J. Quantum Electron. 34, 2006, 1998. [3] D.J Ottaway, P.J. Veitch, C. Hollitt, D. Mudge, M.W Hamilton and J. Munch, Appl. Physics B, 71, 163, 2000. [4] J. Richards and A. McInnes, Opt. Lett. 20, 371, 1995.Item Metadata only 11-Hydroxy-3,3-dimethyl-7,12-dioxo-3,4,6,6a,7,12,12a,12b-octahydrobenz[a]anthracen-1-yl acetate(Munksgaard Int Publ Ltd, 2003) Rozek, T.; Bowie, J.; Skelton, B.; White, A.The Diels-Alder reaction between 5-hydroxy-1,4-naphthoquinone and 5,5-dimethyl-3-vinyl-1,2-cyclohexadienyl acetate by endo addition gives the title compound, C(22)H(22)O(5), in 68% yield. This racemic diastereoisomer has the opposite regiochemistry to ochromycinone analogues produced previously and may allow access to a new type of anticancer-active saquayamycin analogue.Item Metadata only 12mm line survey of the dense molecular gas towards the W28 field TeV gamma-ray sources(Blackwell Publishing Ltd, 2011) Nicholas, B.; Rowell, G.; Burton, M.; Walsh, A.; Fukui, Y.; Kawamura, A.; Longmore, S.; Keto, E.We present 12 mm Mopra observations of dense molecular gas towards the W28 supernova remnant (SNR) field. The focus is on the dense molecular gas towards the TeV gamma-ray sources detected by the HESS telescopes, which likely trace the cosmic rays from W28 and possibly other sources in the region. Using the NH3 inversion transitions we reveal several dense cores inside the molecular clouds, the majority of which coincide with high-mass star formation and H ii regions, including the energetic ultracompact H ii region G5.89−0.39. A key exception to this is the cloud north-east of W28, which is well known to be disrupted as evidenced by clusters of 1720 MHz OH masers and broad CO line emission. Here we detect broad NH3, up to the (9,9) transition, with linewidths up to 16 km s−1. This broad NH3 emission spatially matches well with the TeV source HESS J1801−233 and CO emission, and its velocity dispersion distribution suggests external disruption from the W28 SNR direction. Other lines are detected, such as HC3N and HC5N, H2O masers, and many radio recombination lines, all of which are primarily found towards the southern high-mass star formation regions. These observations provide a new view on to the internal structures and dynamics of the dense molecular gas towards the W28 SNR field and, in tandem with future higher-resolution TeV gamma-ray observations, will offer the chance to probe the transport of cosmic rays into molecular clouds.Item Metadata only 1985 UJ(Minor Planet Center, Smithsonian Astrophysical Observatory, for the International Astronomical Union, 1995) Savage, A.; McNaught, R. H.; Steel, D. I.; Asher, D. J.Item Metadata only 1987 WC(Minor Planet Center, Smithsonian Astrophysical Observatory, for the International Astronomical Union, 1995) Asher, D. J.; Garradd, G. J.; McNaught, R. H.; Steel, D. I.