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1,25-Dihydroxyvitamin D₃ and extracellular calcium promote mineral deposition via NPP1 activity in a mature osteoblast cell line MLO-A5
(Elsevier Ireland Ltd, 2015) Yang, D.; Turner, A.; Wijenayaka, A.; Anderson, P.; Morris, H.; Atkins, G.
Abstract not available.
Open Access
10-Year axillary recurrence in the RACS SNAC1 randomised trial of sentinel lymph node-based management versus routine axillary lymph node dissection
(Elsevier, 2023) Campbell, I.; Wetzig, N.; Ung, O.; Espinoza, D.; Farshid, G.; Collins, J.; Kollias, J.; Gebski, V.; Mister, R.; Simes, R.J.; Stockler, M.R.; Gill, G.
Background: Sentinel node-based management (SNBM) is the international standard of care for early breast cancer that is clinically node-negative based on randomised trials comparing it with axillary lymph node dissection (ALND) and reporting similar rates of axillary recurrence (AR) without distant disease. We report all ARs, overall survival, and breast cancer-specific survival at 10-years in SNAC1. Methods: 1.088 women with clinically node-negative, unifocal breast cancers 3 cm or less in diameter were randomly assigned to either SNBM with ALND if the sentinel node (SN) was positive, or to SN biopsy followed by ALND regardless of SN involvement. Results: First ARs were more frequent in those assigned SNBM rather than ALND (11 events, cumulative risk at 10-years 1⋅85%, 95% CI 0⋅95–3.27% versus 2 events, 0⋅37%, 95% CI 0⋅08–1⋅26%; HR 5⋅47, 95% CI 1⋅21–24⋅63; p = 0⋅013). Disease-free survival, breast cancer-specific survival, and overall survival were similar in those assigned SNBM versus ALND. Lymphovascular invasion was an independent predictor of AR (HR 6⋅6, 95% CI 2⋅25–19⋅36, p < 0⋅001). Conclusion: First ARs were more frequent with SNBM than ALND in women with small, unifocal breast cancers when all first axillary events were considered. We recommend that studies of axillary treatment should report all ARs to give an accurate indication of treatment effects. The absolute frequency of AR was low in women meeting our eligibility criteria, and SNBM should remain the treatment of choice in this group. However, for those with higher-risk breast cancers, further study is needed because the estimated risk of AR might alter their choice of axillary surgery.
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100 Years - Anzac, Vietnam to now
(Elsevier BV, 2015) Atkinson, R.N.; Fraser, R.D.
Abstract not available
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14-3-3:Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival
(Amer Soc Biochemistry Molecular Biology Inc, 2009) Barry, E.; Felquer, F.; Powell, J.; Biggs, L.; Stomski, F.; Urbani, A.; Ramshaw, H.; Hoffmann, P.; Wilce, M.; Grimbaldeston, M.; Lopez, A.; Guthridge, M.
Integrated cascades of protein tyrosine and serine/threonine phosphorylation play essential roles in transducing signals in response to growth factors and cytokines. How adaptor or scaffold proteins assemble signaling complexes through both phosphotyrosine and phosphoserine/threonine residues to regulate specific signaling pathways and biological responses is unclear. We show in multiple cell types that endogenous 14-3-3zeta is phosphorylated on Tyr(179) in response to granulocyte macrophage colony-stimulating factor. Importantly, 14-3-3zeta can function as an intermolecular bridge that couples to phosphoserine residues and also directly binds the SH2 domain of Shc via Tyr(179). The assembly of these 14-3-3:Shc scaffolds is specifically required for the recruitment of a phosphatidylinositol 3-kinase signaling complex and the regulation of CTL-EN cell survival in response to cytokine. The biological significance of these findings was further demonstrated using primary bone marrow-derived mast cells from 14-3-3zeta(-/-) mice. We show that cytokine was able to promote Akt phosphorylation and viability of primary mast cells derived from 14-3-3zeta(-/-) mice when reconstituted with wild type 14-3-3zeta, but the Akt phosphorylation and survival response was reduced in cells reconstituted with the Y179F mutant. Together, these results show that 14-3-3:Shc scaffolds can act as multivalent signaling nodes for the integration of both phosphoserine/threonine and phosphotyrosine pathways to regulate specific cellular responses.
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14-3-3? regulates the procoagulant function of platelets
(Wiley-Blackwell, 2013) Van Der Wal, A.; Cranmer, S.; Ramshaw, H.; Van der Wal, E.; Schoenwaelder, M.; Yuan, Y.; Gardiner, E.; Berndt, M.; Andrews, R.; Lopez, A.; Jackson, S.; 24th Congress of the International Society on Thrombosis and Haemostasis (29 Jun 2013 - 4 Jul 2013 : Amsterdam, The Netherlands)
Open Access
14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain
(Society for Neuroscience, 2014) Toyo-oka, K.; Wachi, T.; Hunt, R.F.; Baraban, S.C.; Taya, S.; Ramshaw, H.; Kaibuchi, K.; Schwarz, Q.P.; Lopez, A.F.; Wynshaw-Boris, A.
During brain development, neural progenitor cells proliferate and differentiate into neural precursors. These neural precursors migrate along the radial glial processes and localize at their final destination in the cortex. Numerous reports have revealed that 14-3-3 proteins are involved in many neuronal activities, although their functions in neurogenesis remain unclear. Here, using 14-3-3ε/ζ double knock-out mice, we found that 14-3-3 proteins are important for proliferation and differentiation of neural progenitor cells in the cortex, resulting in neuronal migration defects and seizures. 14-3-3 deficiency resulted in the increase of δ-catenin and the decrease of β-catenin and αN-catenin. 14-3-3 proteins regulated neuronal differentiation into neurons via direct interactions with phosphorylated δ-catenin to promote F-actin formation through a catenin/Rho GTPase/Limk1/cofilin signaling pathway. Conversely, neuronal migration defects seen in the double knock-out mice were restored by phosphomimic Ndel1 mutants, but not δ-catenin. Our findings provide new evidence that 14-3-3 proteins play important roles in neurogenesis and neuronal migration via the regulation of distinct signaling cascades.
Open Access
14-3-3ζ coordinates adipogenesis of visceral fat
(Nature, 2015) Lim, G.; Albrecht, T.; Piske, M.; Sarai, K.; Lee, J.; Ramshaw, H.; Sinha, S.; Guthridge, M.; Acker-Palmer, A.; Lopez, A.; Clee, S.; Nislow, C.; Johnson, J.
The proteins that coordinate complex adipogenic transcriptional networks are poorly understood. 14-3-3ζ is a molecular adaptor protein that regulates insulin signalling and transcription factor networks. Here we report that 14-3-3ζ-knockout mice are strikingly lean from birth with specific reductions in visceral fat depots. Conversely, transgenic 14-3-3ζ overexpression potentiates obesity, without exacerbating metabolic complications. Only the 14-3-3ζ isoform is essential for adipogenesis based on isoform-specific RNAi. Mechanistic studies show that 14-3-3ζ depletion promotes autophagy-dependent degradation of C/EBP-δ, preventing induction of the master adipogenic factors, Pparγ and C/EBP-α. Transcriptomic data indicate that 14-3-3ζ acts upstream of hedgehog signalling-dependent upregulation of Cdkn1b/p27(Kip1). Indeed, concomitant knockdown of p27(Kip1) or Gli3 rescues the early block in adipogenesis induced by 14-3-3ζ knockdown in vitro. Adipocyte precursors in 14-3-3ζKO embryos also appear to have greater Gli3 and p27(Kip1) abundance. Together, our in vivo and in vitro findings demonstrate that 14-3-3ζ is a critical upstream driver of adipogenesis.
Open Access
14-3-3ζ deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders
(Nature, 2015) Xu, X.; Jaehne, E.; Greenberg, Z.; McCarthy, P.; Saleh, E.; Parish, C.; Camera, D.; Heng, J.; Haas, M.; Baune, B.; Ratnayake, U.; Van Den Buuse, M.; Lopez, A.; Ramshaw, H.; Schwarz, Q.
Sequencing and expression analyses implicate 14-3-3ζ as a genetic risk factor for neurodevelopmental disorders such as schizophrenia and autism. In support of this notion, we recently found that 14-3-3ζ(-/-) mice in the Sv/129 background display schizophrenia-like defects. As epistatic interactions play a significant role in disease pathogenesis we generated a new congenic strain in the BALB/c background to determine the impact of genetic interactions on the 14-3-3ζ(-/-) phenotype. In addition to replicating defects such as aberrant mossy fibre connectivity and impaired spatial memory, our analysis of 14-3-3ζ(-/-) BALB/c mice identified enlarged lateral ventricles, reduced synaptic density and ectopically positioned pyramidal neurons in all subfields of the hippocampus. In contrast to our previous analyses, 14-3-3ζ(-/-) BALB/c mice lacked locomotor hyperactivity that was underscored by normal levels of the dopamine transporter (DAT) and dopamine signalling. Taken together, our results demonstrate that dysfunction of 14-3-3ζ gives rise to many of the pathological hallmarks associated with the human condition. 14-3-3ζ-deficient BALB/c mice therefore provide a novel model to address the underlying biology of structural defects affecting the hippocampus and ventricle, and cognitive defects such as hippocampal-dependent learning and memory.
Open Access
14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
(Nature Publishing Group, 2016) Schoenwaelder, S.M.; Darbousset, R.; Cranmer, S.L.; Ramshaw, H.S.; Orive, S.L.; Sturgeon, S.; Yuan, Y.; Yao, Y.; Krycer, J.R.; Woodcock, J.; Maclean, J.; Pitson, S.; Zheng, Z.; Henstridge, D.C.; Van Der Wal, D.; Gardiner, E.E.; Berndt, M.C.; Andrews, R.K.; James, D.E.; Lopez, A.F.; et al.
The 14-3-3 family of adaptor proteins regulate diverse cellular functions including cell proliferation, metabolism, adhesion and apoptosis. Platelets express numerous 14-3-3 isoforms, including 14-3-3z, which has previously been implicated in regulating GPIba function. Here we show an important role for 14-3-3z in regulating arterial thrombosis. Interestingly, this thrombosis defect is not related to alterations in von Willebrand factor (VWF)–GPIb adhesive function or platelet activation, but instead associated with reduced platelet phosphatidylserine (PS) exposure and procoagulant function. Decreased PS exposure in 14-3-3z-deficient platelets is associated with more sustained levels of metabolic ATP and increased mitochondrial respiratory reserve, independent of alterations in cytosolic calcium flux. Reduced platelet PS exposure in 14-3-3z-deficient mice does not increase bleeding risk, but results in decreased thrombin generation and protection from pulmonary embolism, leading to prolonged survival. Our studies define an important role for 14-3-3z in regulating platelet bioenergetics, leading to decreased platelet PS exposure and procoagulant function.
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18F-FDG-PET/CT in the assessment of pancreatic cancer: is the contrast or a better-designed trial needed?
(Blackwell Publishing Asia, 2011) Nguyen, Q.; Bartholomeusz, D.
See article in J. Gastroenterol. Hepatol. 2011; 26: 657–662.
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1α,25-dihydroxyvitamin D3 stimulates human SOST gene expression and sclerostin secretion
(Elsevier Ireland Ltd, 2015) Wijenayaka, A.; Yang, D.; Prideaux, M.; Ito, N.; Kogawa, M.; Anderson, P.; Morris, H.; Solomon, L.; Loots, G.; Findlay, D.; Atkins, G.
Abstract not available
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2-year outcomes after stenting of lipid-rich and nonrich coronary plaques
(Elsevier, 2020) Yamamoto, M.H.; Maehara, A.; Stone, G.W.; Kini, A.S.; Brilakis, E.S.; Rizik, D.G.; Shunk, K.; Powers, E.R.; Tobis, J.M.; Maini, B.S.; Dixon, S.R.; Goldstein, J.A.; Petersen, J.L.; Généreux, P.; Shah, P.R.; Crowley, A.; Nicholls, S.J.; Mintz, G.S.; Muller, J.E.; Weisz, G.
Background: Autopsy studies suggest that implanting stents in lipid-rich plaque (LRP) may be associated with adverse outcomes. Objectives: The purpose of this study was to evaluate the association between LRP detected by near-infrared spectroscopy (NIRS) and clinical outcomes in patients with coronary artery disease treated with contemporary drug-eluting stents. Methods: In this prospective, multicenter registry, NIRS was performed in patients undergoing coronary angiography and possible percutaneous coronary intervention (PCI). Lipid core burden index (LCBI) was calculated as the fraction of pixels with the probability of LRP >0.6 within a region of interest. MaxLCBI4mm was defined as the maximum LCBI within any 4-mm-long segment. Major adverse cardiac events (MACE) included cardiac death, myocardial infarction, definite or probable stent thrombosis, or unplanned revascularization or rehospitalization for progressive angina or unstable angina. Events were subcategorized as culprit (treated) lesion–related, nonculprit (untreated) lesion–related, or indeterminate. Results: Among 1,999 patients who were enrolled in the COLOR (Chemometric Observations of Lipid Core Plaques of Interest in Native Coronary Arteries Registry), PCI was performed in 1,621 patients and MACE occurred in 18.0% of patients, of which 8.3% were culprit lesion–related, 10.7% were nonculprit lesion–related, and 3.1% were indeterminate during 2-year follow-up. Complications from NIRS imaging occurred in 9 patients (0.45%), which resulted in 1 peri-procedural myocardial infarction and 1 emergent coronary bypass. Pre-PCI NIRS imaging was obtained in 1,189 patients, and the 2-year rate of culprit lesion–related MACE was not significantly associated with maxLCBI4mm (hazard ratio of maxLCBI4mm per 100: 1.06; 95% confidence interval: 0.96 to 1.17; p = 0.28) after adjusting clinical and procedural factors. Conclusions: Following PCI with contemporary drug-eluting stents, stent implantation in NIRS-defined LRPs was not associated with increased periprocedural or late adverse outcomes compared with those without significant lipid.
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2009 ISSLS prize winner: What influence does sustained mechanical load have on diffusion in the human intervertebral disc? An in vivo study using serial postcontrast magnetic resonance imaging
(Lippincott Williams & Wilkins, 2009) Ranganathan, A.; Freeman, B.; Scammell, B.; McNally, D.; Cox, E.; Gowland, P.
Study Design: An in vivo study of the effects of mechanical loading on transport of small solutes into normal human lumbar intervertebral discs (IVD) using serial postcontrast magnetic resonance imaging (MRI). Objective: To investigate the influence of a sustained mechanical load on diffusion of small solutes in and out of the normal IVD. Summary of Background Data: Diffusion is an important source of disc nutrition and the in vivo effects of load on diffusion in human IVD remains unknown. Methods: Forty normal lumbar discs (on MRI) in 8 healthy volunteers were subjected to serial post contrast (Gadoteridol) 3 Tesla MRI in 2 phases. In phase 1 (control), volunteers were scanned at different time points – precontrast and 1.5, 3, 4.5, 6, and 7.5 hours postcontrast injection. In phase 2, 1 month later, the same volunteers were subjected to sustained supine loading for 4.5 hours. MRI scans were performed precontrast (preload) and postcontrast (postloading) at 1.5, 3, and 4.5 hours. Their spines were then unloaded and recovery scans performed at 6 and 7.5 hours postcontrast. In house software was used to analyze images. Results: Repeated-measures ANOVA and pairwise comparisons at different time points in the central region of the loaded disc (LD) compared to the unloaded discs (UD) revealed significantly lower signal intensity ratios (P1.5h:P3h:P4.5h<0.001:<0.001:<0.002) indicating reduction in transport rates for the LDs. Signal intensity ratios continued to rise in LD for 3 hours into recovery phase,whereas UD at the same time point showed a decrease (mean ± SD = 0.08 ± 0.08 vs. -0.21 ± 0.03). Conclusion: Sustained supine creep loading (50% body weight) for 4.5 hours retards transport of small solutes into the center of human IVD and it required 3 hours of accelerated diffusion in recovery state for LD to catch-up with diffusion in UD. The study supports the theory that sustained mechanical loading impairs diffusion of nutrients entering the disc and quite possibly accelerates disc degeneration.
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2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope
(Elsevier, 2015) Sheldon, R.; Grubb, B.; Olshansky, B.; Shen, W.; Calkins, H.; Brignole, M.; Raj, S.; Krahn, A.; Morillo, C.; Stewart, J.; Sutton, R.; Sandroni, P.; Friday, K.; Hachul, D.; Cohen, M.; Lau, D.; Mayuga, K.; Moak, J.; Sandhu, R.; Kanjwal, K.
Abstract not available
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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
(Oxford University Press, 2016) Kirchhof, P.; Benussi, S.; Kotecha, D.; Ahlsson, A.; Atar, D.; Casadei, B.; Castella, M.; Diener, H.C.; Heidbuchel, H.; Hendriks, J.; Hindricks, G.; Manolis, A.S.; Oldgren, J.; Popescu, B.A.; Schotten, U.; Van Putte, B.; Vardas, P.; Agewall, S.; Camm, J.; Baron Esquivias, G.; et al.
Abstract not available
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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
(Oxford University Press, 2016) Kirchhof, P.; Benussi, S.; Kotecha, D.; Ahlsson, A.; Atar, D.; Casadei, B.; Castella, M.; Diener, H.C.; Heidbuchel, H.; Hendriks, J.; Hindricks, G.; Manolis, A.S.; Oldgren, J.; Popescu, B.A.; Schotten, U.; Van Putte, B.; Vardas, P.; Agewall, S.; Camm, J.; Baron Esquivias, G.; et al.
Guidelines summarize and evaluate all available evidence on a particular issue at the time of the writing process, with the aim of assisting health professionals in selecting the best management strategies for an individual patient with a given condition, taking into account the impact on outcome, as well as the risk–benefit ratio of particular diagnostic or therapeutic means. Guidelines and recommendations should help health professionals to make decisions in their daily practice. However, the final decisions concerning an individual patient must be made by the responsible health professional(s) in consultation with the patient and caregiver as appropriate. A great number of Guidelines have been issued in recent years by the European Society of Cardiology (ESC) and by the European Association for Cardio-Thoracic Surgery (EACTS), as well as by other societies and organisations. Because of the impact on clinical practice, quality criteria for the development of guidelines have been established in order to make all decisions transparent to the user. The recommendations for formulating and issuing ESC Guidelines can be found on the ESC website (http://www.escardio.org/Guidelines-&-Education/Clinical-Practice-Guidelines/Guidelines-development/Writing-ESC-Guidelines). ESC Guidelines represent the official position of the ESC on a given topic and are regularly updated. Members of this Task Force were selected by the ESC, including representation from the European Heart Rhythm Association (EHRA), and EACTS as well as by the European Stroke Organisation (ESO) to represent professionals involved with the medical care of patients with this pathology. Selected experts in the field undertook a comprehensive review of the published evidence for management (including diagnosis, treatment, prevention and rehabilitation) of a given condition according to ESC Committee for Practice Guidelines (CPG) policy and approved by the EACTS and ESO. A critical evaluation of diagnostic and therapeutic procedures was performed, including assessment of the risk–benefit ratio. Estimates of expected health outcomes for larger populations were included, where data exist. The level of evidence and the strength of the recommendation of particular management options were weighed and graded according to predefined scales, as outlined in Tables 1 and 2.
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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
(European Society of Cardiology, 2016) Kirchhof, P.; Benussi, S.; Kotecha, D.; Ahlsson, A.; Atar, D.; Casadei, B.; Castella, M.; Diener, H.-C.; Heidbuchel, H.; Hendriks, J.; Hindricks, G.; Manolis, A.; Oldgren, J.; Popescu, B.; Schotten, U.; Van Putte, B.; Vardas, P.; Agewall, S.; Camm, J.; Baron Esquivias, G.; et al.
Abstract not available
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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
(Viamedica International Healthcare, 2016) Kirchhof, P.; Benussi, S.; Kotecha, D.; Ahlsson, A.; Atar, D.; Casadei, B.; Castella, M.; Diener, H.C.; Heidbuchel, H.; Hendriks, J.; Hindricks, G.; Manolis, A.S.; Oldgren, J.; Popescu, B.A.; Schotten, U.; Van Putte, B.; Vardas, P.
Wytyczne ESC reprezentują stanowisko tego towarzystwa i powstały po dokładnej ocenie dowodów naukowych dostępnych w czasie, kiedy przygotowywano niniejszy dokument. European Society of Cardiology nie ponosi odpowiedzialności w przypadku jakichkolwiek sprzeczności, rozbieżności i/lub niejednoznaczności między wytycznymi ESC a jakimikolwiek innymi oficjalnymi zaleceniami lub wytycznymi wydanymi przez odpowiednie instytucje zdrowia publicznego, zwłaszcza w odniesieniu do właściwego wykorzystywania strategii opieki zdrowotnej lub leczenia. Zachęca się pracowników opieki zdrowotnej, aby w pełni uwzględniali te wytyczne ESC, gdy dokonują oceny klinicznej, a także kiedy określają i realizują medyczne strategie prewencji, diagnostyki lub leczenia. Wytyczne nie znoszą jednak w żaden sposób indywidualnej odpowiedzialności pracowników opieki zdrowotnej za podejmowanie właściwych i dokładnych decyzji z uwzględnieniem stanu zdrowia danego pacjenta i po konsultacji z danym pacjentem oraz, jeżeli jest to właściwe i/lub konieczne, z opiekunem pacjenta. Wytyczne ESC nie zwalniają też pracowników opieki zdrowotnej z konieczności pełnego i dokładnego rozważenia odpowiednich, oficjalnych uaktualnionych zaleceń lub wytycznych wydanych przez kompetentne instytucje zdrowia publicznego w celu odpowiedniego postępowania z każdym pacjentem w świetle naukowo akceptowanych danych odnoszących się do ich zobowiązań etycznych i zawodowych. Na pracownikach opieki zdrowotnej spoczywa odpowiedzialność za weryfikację zasad i przepisów odnoszących się do leków i urządzeń w momencie ich stosowania (przepisywania).
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2016 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy- induced nausea and vomiting and of nausea and vomiting in advanced cancer patients
(Oxford University Press, 2016) Roila, F.; Molassiotis, A.; Herrstedt, J.; Aapro, M.; Gralla, R.; Bruera, E.; Clark-Snow, R.; Dupuis, L.; Einhorn, L.; Feyer, P.; Hesketh, P.; Jordan, K.; Olver, I.; Rapoport, B.; Roscoe, J.; Ruhlmann, C.; Walsh, D.; Warr, D.; van der Wetering, M.; on, B.O.T.P.O.T.M.C.C.C.
Despite the considerable progress achieved in the last 30 years, vomiting and, especially, nausea, continue to be two of the most distressing side-effects of cancer chemotherapy. In the late 1990s, several professional organisations published recommendations on the optimal antiemetic prophylaxis in patients submitted to chemotherapy and/or radiotherapy. The European Society of Medical Oncology (ESMO) and the Multinational Association of Supportive Care in Cancer (MASCC) published the results of the third Consensus Conference on antiemetics held in Perugia in June 2009 in Annals of Oncology in 2010 [1]. An update of these recommendations, including studies published from 1 January 2009 to 30 June 2015, was discussed in Copenhagen in June 2015 and is presented in this paper. The methodology for the guideline process is described in detail in the 2010 publication [1]. To change a 2010 recommendation or for a new guideline recommendation to be accepted, a consensus of at least 67% of the expert panellists was needed. As a general rule, the panel considered changes of 10% or greater to be sufficient to warrant the changing of a recommendation.
Open Access
2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation
(Elsevier, 2017) Calkins, H.; Hindricks, G.; Cappato, R.; Kim, Y.; Saad, E.; Aguinaga, L.; Akar, J.; Badhwar, V.; Brugada, J.; Camm, J.; Chen, P.; Chen, S.; Chung, M.; Nielsen, J.; Curtis, A.; Davies, D.; Day, J.; d'Avila, A.; de Groot, N.; Di Biase, L.; et al.
Abstract not available

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