Assessing Seminal Fluid Interaction with Female Reproductive Tract Tissues: In Vivo and In Vitro Models for Mouse

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dc.contributor.authorChan, H.Y.
dc.contributor.authorSchjenken, J.E.
dc.contributor.authorSharkey, D.J.
dc.contributor.authorRobertson, S.A.
dc.contributor.editorÁlvarez-Rodríguez, M.
dc.date.issued2025
dc.descriptionSeries Editor John M. Walker, Print ISSN 1064-3745 ; Electronic ISSN 1940-6029.
dc.description.abstractAfter intromission of seminal fluid at mating in mammals, the seminal fluid interacts with the lining of the female reproductive tract and elicits a female immune response. This response is triggered by signals in seminal fluid (carried by both the sperm and seminal plasma components) that bind receptors on female tract epithelial cells, causing a change in their transcriptional program to upregulate expression of pro-inflammatory cytokines and chemokines. The ensuing leukocyte recruitment and immune activation facilitates conception, embryo development, and progression of pregnancy. In this chapter, we report methods for evaluating effects of seminal fluid and its components (seminal plasma and sperm) on the female reproductive tract immune response in mice.
dc.description.statementofresponsibilityHon Yeung Chan, John E. Schjenken, David J. Sharkey, and Sarah A. Robertson
dc.identifier.citationSpermatology: Methods and Protocols, 2025 / Álvarez-Rodríguez, M. (ed./s), vol.2897, Ch.44, pp.649-662
dc.identifier.doi10.1007/978-1-0716-4406-5_44
dc.identifier.isbn978-1-0716-4406-5
dc.identifier.orcidSchjenken, J.E. [0000-0001-6293-6160]
dc.identifier.orcidSharkey, D.J. [0000-0002-4831-7950]
dc.identifier.orcidRobertson, S.A. [0000-0002-9967-0084]
dc.identifier.urihttps://hdl.handle.net/2440/148365
dc.language.isoen
dc.publisherHumana Press
dc.publisher.placeNew York, NY, USA
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1041335
dc.relation.granthttp://purl.org/au-research/grants/arc/DP220103487
dc.relation.granthttp://purl.org/au-research/grants/arc/DP160102366
dc.relation.ispartofseriesMethods in Molecular Biology; 2897
dc.rights© The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2025
dc.source.urihttps://doi.org/10.1007/978-1-0716-4406-5
dc.subjectSeminal fluid; Seminal plasma; Sperm; Uterus; Cervix; Inflammation; Mice
dc.subject.meshGenitalia, Female
dc.subject.meshSpermatozoa
dc.subject.meshSemen
dc.subject.meshAnimals
dc.subject.meshMice
dc.subject.meshPregnancy
dc.subject.meshFemale
dc.subject.meshMale
dc.titleAssessing Seminal Fluid Interaction with Female Reproductive Tract Tissues: In Vivo and In Vitro Models for Mouse
dc.typeBook chapter
pubs.publication-statusPublished

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