Gastric emptying is slower in women than men with type 2 diabetes and impacts on postprandial glycaemia
Date
2024
Authors
Xiang, C.
Sun, Y.
Luo, Y.
Xie, C.
Huang, W.
Jones, K.L.
Horowitz, M.
Sun, Z.
Rayner, C.K.
Ma, J.
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Advisors
Journal Title
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Journal article
Citation
Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics, 2024; 26(8):3119-3127
Statement of Responsibility
Chunjie Xiang, Yixuan Sun, Yong Luo, Cong XiD, Weikun Huang, Karen L. Jones, Michael Horowitz, Zilin Sun, Christopher K. Rayner, Jianhua Ma, Tongzhi Wu
Conference Name
Abstract
AIM: To evaluate sex differences in gastric emptying and the glycaemic response to a glucose drink and a high carbohydrate meal in type 2 diabetes (T2D). METHODS: In cohort 1, 70 newly diagnosed, treatment-naïve Chinese patients with T2D (44 men) recruited from a diabetes outpatient clinic ingested a 75-g glucose drink containing 150 mg 13C-acetate. In cohort 2, 101 Australian patients with T2D (67 male) recruited from the community, managed by diet and/or metformin monotherapy, ingested a semi-solid mashed potato meal, labelled with 100 μl 13C-octanoic acid. Breath samples were collected over 3 and 4 h, respectively, for assessment of gastric emptying, and venous blood was sampled for evaluation of glycaemia (with and without adjustment for each participant's estimated total blood volume). RESULTS: Gastric emptying was slower in female than male subjects in both cohorts (both p < .01). Multiple linear regression analyses revealed that gastric emptying was independently associated with sex (both p < .05). Without adjustment for blood volume, the glycaemic responses to oral glucose and the mixed meal were greater in female subjects (both p < .001). However, after adjustment for blood volume, the glycaemic responses were greater in men (both p < .05). CONCLUSIONS: Gastric emptying is slower in women than men with T2D, associated with a reduced blood volume-adjusted glycaemic response to oral glucose and a mixed meal in women. These observations highlight the sex difference in postprandial glucose handling, which is relevant to the personalized management of postprandial glycaemia in T2D.
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Dissertation Note
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© 2024 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.