Gastric emptying is slower in women than men with type 2 diabetes and impacts on postprandial glycaemia

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dc.contributor.authorXiang, C.
dc.contributor.authorSun, Y.
dc.contributor.authorLuo, Y.
dc.contributor.authorXie, C.
dc.contributor.authorHuang, W.
dc.contributor.authorJones, K.L.
dc.contributor.authorHorowitz, M.
dc.contributor.authorSun, Z.
dc.contributor.authorRayner, C.K.
dc.contributor.authorMa, J.
dc.contributor.authorWu, T.
dc.date.issued2024
dc.description.abstractAIM: To evaluate sex differences in gastric emptying and the glycaemic response to a glucose drink and a high carbohydrate meal in type 2 diabetes (T2D). METHODS: In cohort 1, 70 newly diagnosed, treatment-naïve Chinese patients with T2D (44 men) recruited from a diabetes outpatient clinic ingested a 75-g glucose drink containing 150 mg 13C-acetate. In cohort 2, 101 Australian patients with T2D (67 male) recruited from the community, managed by diet and/or metformin monotherapy, ingested a semi-solid mashed potato meal, labelled with 100 μl 13C-octanoic acid. Breath samples were collected over 3 and 4 h, respectively, for assessment of gastric emptying, and venous blood was sampled for evaluation of glycaemia (with and without adjustment for each participant's estimated total blood volume). RESULTS: Gastric emptying was slower in female than male subjects in both cohorts (both p < .01). Multiple linear regression analyses revealed that gastric emptying was independently associated with sex (both p < .05). Without adjustment for blood volume, the glycaemic responses to oral glucose and the mixed meal were greater in female subjects (both p < .001). However, after adjustment for blood volume, the glycaemic responses were greater in men (both p < .05). CONCLUSIONS: Gastric emptying is slower in women than men with T2D, associated with a reduced blood volume-adjusted glycaemic response to oral glucose and a mixed meal in women. These observations highlight the sex difference in postprandial glucose handling, which is relevant to the personalized management of postprandial glycaemia in T2D.
dc.description.statementofresponsibilityChunjie Xiang, Yixuan Sun, Yong Luo, Cong XiD, Weikun Huang, Karen L. Jones, Michael Horowitz, Zilin Sun, Christopher K. Rayner, Jianhua Ma, Tongzhi Wu
dc.identifier.citationDiabetes, Obesity and Metabolism, 2024; 26(8):3119-3127
dc.identifier.doi10.1111/dom.15635
dc.identifier.issn1462-8902
dc.identifier.issn1463-1326
dc.identifier.orcidSun, Y. [0000-0002-8759-0474]
dc.identifier.orcidXie, C. [0000-0002-0054-9269]
dc.identifier.orcidHuang, W. [0000-0001-9400-3840]
dc.identifier.orcidJones, K.L. [0000-0002-1155-5816]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidRayner, C.K. [0000-0002-5527-256X]
dc.identifier.orcidWu, T. [0000-0003-1656-9210]
dc.identifier.urihttps://hdl.handle.net/2440/141959
dc.language.isoen
dc.publisherWiley
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1147333
dc.rights© 2024 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1111/dom.15635
dc.subjectgastric emptying
dc.subjectpostprandial glycaemia
dc.subjectsex disparity
dc.subjecttype 2 diabetes
dc.subject.meshHumans
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshHyperglycemia
dc.subject.meshMetformin
dc.subject.meshDietary Carbohydrates
dc.subject.meshGlucose
dc.subject.meshBlood Glucose
dc.subject.meshHypoglycemic Agents
dc.subject.meshBreath Tests
dc.subject.meshCohort Studies
dc.subject.meshSex Factors
dc.subject.meshGastric Emptying
dc.subject.meshPostprandial Period
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshMiddle Aged
dc.subject.meshChina
dc.subject.meshAustralia
dc.subject.meshFemale
dc.subject.meshMale
dc.titleGastric emptying is slower in women than men with type 2 diabetes and impacts on postprandial glycaemia
dc.typeJournal article
pubs.publication-statusPublished

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