The role of genes and environment in human dental arch shape - a twin study
| dc.contributor.author | Lin, T.-H. | |
| dc.contributor.author | Meade, M. | |
| dc.contributor.author | Hughes, T.E. | |
| dc.contributor.conference | Annual Meeting of the American Association of Biological Anthropologists (AABA) (20 Mar 2024 - 23 Mar 2024 : Los Angeles, California) | |
| dc.date.issued | 2024 | |
| dc.description | Abstract | |
| dc.description.abstract | Objective: To assess the contribution of genes to shape variation in permanent dental arches of individuals of Western European descent. Methods: Subjects consisted of dental casts from 64 monozygotic and 38 dizygotic twins, housed in the Adelaide Dental School, Australia. Subjects were of Western European descent, with a mean age of 19.4 ± 5.4 years. Casts were scanned digitally, and landmarks placed cusp tips of teeth. Geometric morphometrics were applied to examine shape variation within arch. Two-block partial least squares analysis was used to assess shape covariation between arches. Structural equation modelling was utilised to decompose shape variation into genetic and environmental components. Results: The ܪrst three principal components (PCs) of the maxillary and mandibular arch accounted for 53% and 50% of variation in shape space, respectively. PCs represented shape variability as follows: PC1 - arch depth-width ratio; PC2 - arch taper, canine position (and ܪrst premolar rotation for the mandibular arch); PC3 - incisor displacement and rotation. A model incorporating additive genetic and unique environmental factors optimally explained the observed variation for all PCs. Variation in maxillary and mandibular arch shapes exhibited moderate to high heritability (0.61-0.74). Upper and lower dental arches had strong and signiܪcant shape covariation, with high heritability in their reciprocal inܫuences on shape (h2 = 0.72~0.74, rpls coefܪcient= 0.87, p<0.05).Conclusion: In this cohort, dental arch shape variation was predominantly inܫuenced by genetic factors. This information may help underpin the shape of the dental arches as a useful measure of evolutionary change. | |
| dc.description.statementofresponsibility | Ting-Han Lin, Maurice Meade and Toby E. Hughes | |
| dc.identifier.citation | American Journal of Physical Anthropology, 2024, vol.183, iss.Suppl. 77, pp.102-102 | |
| dc.identifier.doi | 10.1002/ajpa.24928 | |
| dc.identifier.issn | 2692-7691 | |
| dc.identifier.issn | 2692-7691 | |
| dc.identifier.orcid | Meade, M. [0000-0001-5688-1079] | |
| dc.identifier.orcid | Hughes, T.E. [0000-0001-8668-7744] | |
| dc.identifier.uri | https://hdl.handle.net/2440/142637 | |
| dc.language.iso | en | |
| dc.publisher | Wiley | |
| dc.relation.grant | NHMRC | |
| dc.rights | © 2024 Wiley Periodicals LLC. | |
| dc.source.uri | https://onlinelibrary.wiley.com/toc/26927691/2024/183/S77 | |
| dc.subject | Geometric morphometrics | |
| dc.title | The role of genes and environment in human dental arch shape - a twin study | |
| dc.type | Conference item | |
| pubs.publication-status | Published |