Disparities in gastric emptying and postprandial glycaemia between Han Chinese and Caucasians with type 2 diabetes.
Date
2020
Authors
Wang, X.
Xie, C.
Marathe, C.S.
Malbert, C.-H.
Horowitz, M.
Jones, K.L.
Rayner, C.K.
Sun, Z.
Wu, T.
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Journal article
Citation
Diabetes Research and Clinical Practice, 2020; 159:107951-1-107951-6
Statement of Responsibility
Xuyi Wang, Cong Xie, Chinmay S. Marathe, Charles-Henri Malbert, Michael Horowitz, Karen L. Jones, Christopher K. Rayner, Zilin Sun, Tongzhi Wu
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Abstract
Aims: Gastric emptying is a major determinant of postprandial glycaemia in both health and type 2 diabetes (T2DM); the potential impact of ethnicity on gastric emptying is unclear. We compared the rate of gastric emptying of a standardised meal and the associated glycaemic response in Han Chinese and Caucasian patients with T2DM. Methods: 14 Han Chinese and 14 Caucasian T2DM patients, managed by diet and/or metformin monotherapy, underwent concurrent measurements of gastric emptying and blood glucose for 240 min after a 99mTc-calcium phytate-labelled mashed potato meal. Results: Han Chinese patients were slightly younger (P < 0.05), and had a lower BMI (P < 0.05), than Caucasians. There were no differences in either HbA1c or fasting blood glucose between them. Gastric half-emptying time (T50) was shorter (P < 0.05) and the postprandial blood glucose increment greater (P < 0.05) in Han Chinese than Caucasian patients. Both the increment in blood glucose from baseline at 60 min and peak blood glucose were related inversely to T50 (P < 0.05 each). Conclusions: Han Chinese with relatively well-controlled T2DM have more rapid gastric emptying compared to Caucasians, which is associated with a greater postprandial glycaemic excursion. These differences may inform the choice of management, e.g. Han Chinese may particularly benefit from therapies that slow gastric emptying.
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© 2019 Elsevier B.V. All rights reserved.