Disparities in gastric emptying and postprandial glycaemia between Han Chinese and Caucasians with type 2 diabetes.

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dc.contributor.authorWang, X.
dc.contributor.authorXie, C.
dc.contributor.authorMarathe, C.S.
dc.contributor.authorMalbert, C.-H.
dc.contributor.authorHorowitz, M.
dc.contributor.authorJones, K.L.
dc.contributor.authorRayner, C.K.
dc.contributor.authorSun, Z.
dc.contributor.authorWu, T.
dc.date.issued2020
dc.description.abstractAims: Gastric emptying is a major determinant of postprandial glycaemia in both health and type 2 diabetes (T2DM); the potential impact of ethnicity on gastric emptying is unclear. We compared the rate of gastric emptying of a standardised meal and the associated glycaemic response in Han Chinese and Caucasian patients with T2DM. Methods: 14 Han Chinese and 14 Caucasian T2DM patients, managed by diet and/or metformin monotherapy, underwent concurrent measurements of gastric emptying and blood glucose for 240 min after a 99mTc-calcium phytate-labelled mashed potato meal. Results: Han Chinese patients were slightly younger (P < 0.05), and had a lower BMI (P < 0.05), than Caucasians. There were no differences in either HbA1c or fasting blood glucose between them. Gastric half-emptying time (T50) was shorter (P < 0.05) and the postprandial blood glucose increment greater (P < 0.05) in Han Chinese than Caucasian patients. Both the increment in blood glucose from baseline at 60 min and peak blood glucose were related inversely to T50 (P < 0.05 each). Conclusions: Han Chinese with relatively well-controlled T2DM have more rapid gastric emptying compared to Caucasians, which is associated with a greater postprandial glycaemic excursion. These differences may inform the choice of management, e.g. Han Chinese may particularly benefit from therapies that slow gastric emptying.
dc.description.statementofresponsibilityXuyi Wang, Cong Xie, Chinmay S. Marathe, Charles-Henri Malbert, Michael Horowitz, Karen L. Jones, Christopher K. Rayner, Zilin Sun, Tongzhi Wu
dc.identifier.citationDiabetes Research and Clinical Practice, 2020; 159:107951-1-107951-6
dc.identifier.doi10.1016/j.diabres.2019.107951
dc.identifier.issn0168-8227
dc.identifier.issn1872-8227
dc.identifier.orcidXie, C. [0000-0002-0054-9269]
dc.identifier.orcidMalbert, C.-H. [0000-0002-0665-4545]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidJones, K.L. [0000-0002-1155-5816]
dc.identifier.orcidRayner, C.K. [0000-0002-5527-256X]
dc.identifier.orcidWu, T. [0000-0003-1656-9210]
dc.identifier.urihttps://hdl.handle.net/2440/145902
dc.language.isoen
dc.publisherElsevier
dc.rights© 2019 Elsevier B.V. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.diabres.2019.107951
dc.subjectEthnicity; Gastric emptying; Postprandial glycaemia; Type 2 diabetes
dc.subject.meshHumans
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshGastric Emptying
dc.subject.meshPostprandial Period
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshChild
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshHealthcare Disparities
dc.subject.meshYoung Adult
dc.titleDisparities in gastric emptying and postprandial glycaemia between Han Chinese and Caucasians with type 2 diabetes.
dc.typeJournal article
pubs.publication-statusPublished

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