Cancer-related Fatigue in Lung Cancer: A Research Agenda: An Official American Thoracic Society Research Statement

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dc.contributor.authorBade, B.C.
dc.contributor.authorFaiz, S.A.
dc.contributor.authorHa, D.M.
dc.contributor.authorTan, M.
dc.contributor.authorBarton-Burke, M.
dc.contributor.authorCheville, A.L.
dc.contributor.authorEscalante, C.P.
dc.contributor.authorGozal, D.
dc.contributor.authorGranger, C.L.
dc.contributor.authorPresley, C.J.
dc.contributor.authorSmith, S.M.
dc.contributor.authorChamberlaine, D.M.
dc.contributor.authorLong, J.M.
dc.contributor.authorMalone, D.J.
dc.contributor.authorPirl, W.F.
dc.contributor.authorRobinson, H.L.
dc.contributor.authorYasufuku, K.
dc.contributor.authorRivera, M.P.
dc.date.issued2023
dc.description.abstractBackground: Fatigue is the most common symptom among cancer survivors. Cancer-related fatigue (CRF) may occur at any point in the cancer care continuum. Multiple factors contribute to CRF development and severity, including cancer type, treatments, presence of other symptoms, comorbidities, and medication side effects. Clinically, increasing physical activity, enhancing sleep quality, and recognizing sleep disorders are integral to managing CRF. Unfortunately, CRF is infrequently recognized, evaluated, or treated in lung cancer survivors despite more frequent and severe symptoms than in other cancers. Therefore, increased awareness and understanding of CRF are needed to improve health-related quality of life in lung cancer survivors. Objectives: 1) To identify and prioritize knowledge and research gaps and 2) to develop and prioritize research questions to evaluate mechanistic, diagnostic, and therapeutic approaches to CRF among lung cancer survivors. Methods: We convened a multidisciplinary panel to review the available literature on CRF, focusing on the impacts of physical activity, rehabilitation, and sleep disturbances in lung cancer. We used a three-round modified Delphi process to prioritize research questions. Results: This statement identifies knowledge gaps in the 1) detection and diagnostic evaluation of CRF in lung cancer survivors; 2) timing, goals, and implementation of physical activity and rehabilitation; and 3) evaluation and treatment of sleep disturbances and disorders to reduce CRF. Finally, we present the panel’s initial 32 research questions and seven final prioritized questions. Conclusions: This statement offers a prioritized research agenda to 1) advance clinical and research efforts and 2) increase awareness of CRF in lung cancer survivors.
dc.description.statementofresponsibilityBrett C. Bade, Saadia A. Faiz, Duc M. Ha, Miranda Tan, Margaret Barton-Burke, Andrea L. Cheville, Carmen P. Escalante, David Gozal, Catherine L. Granger, Carolyn J. Presley, Sheree M. Smith, Dawn M. Chamberlaine, Jason M. Long, Daniel J. Malone, William F. Pirl, Halley L. Robinson, Kazuhiro Yasufuku, and M. Patricia Rivera; on behalf of the American Thoracic Society Assembly on Thoracic Oncology
dc.identifier.citationAmerican Journal of Respiratory and Critical Care Medicine, 2023; 207(5):e6-e28
dc.identifier.doi10.1164/rccm.202210-1963st
dc.identifier.issn1073-449X
dc.identifier.issn1535-4970
dc.identifier.orcidSmith, S.M. [0000-0002-7469-1022]
dc.identifier.urihttps://hdl.handle.net/2440/144500
dc.language.isoen
dc.publisherAmerican Thoracic Society
dc.rights© 2023 by the American Thoracic Society. 🔓 You may print one copy of this document at no charge. However, if you require more than one copy, you must place a reprint order. Domestic reprint orders: amy.schriver@sheridan.com; international reprint orders: louisa.mott@springer.com.
dc.source.urihttp://dx.doi.org/10.1164/rccm.202210-1963st
dc.subjectlung cancer; cancer-related fatigue; physical activity; rehabilitation; exercise training; sleep disturbance; sleep disorder; survivorship
dc.subject.meshHumans
dc.subject.meshLung Neoplasms
dc.subject.meshFatigue
dc.subject.meshQuality of Life
dc.subject.meshSurvivors
dc.subject.meshSleep Wake Disorders
dc.subject.meshEvidence Gaps
dc.titleCancer-related Fatigue in Lung Cancer: A Research Agenda: An Official American Thoracic Society Research Statement
dc.typeJournal article
pubs.publication-statusPublished

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