Plasma atrial natriuretic peptide in patients with acute myocardial infarction: effects of streptokinase
Date
1989
Authors
Phillips, P.
Sasadeus, J.
Hodsman, G.
Horowitz, J.
Saltups, A.
Johnston, C.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Heart, 1989; 61(2):139-143
Statement of Responsibility
P A Phillips, J Sasadeus, G P Hodsman, J Horowitz, A Saltups, C I Johnston
Conference Name
Abstract
Plasma concentrations of immunoreactive atrial natriuretic peptide (mean (SEM] were measured in 135 patients admitted to two coronary care units with myocardial infarction, ischaemic chest pain, or non-ischaemic chest pain. Concentrations were significantly higher in patients with acute myocardial infarction not treated with systemic thrombolysis (60.4 (14.3) pg/ml) than in patients with non-ischaemic chest pain (21.1 (4.3) pg/ml). Patients with ischaemic chest pain had intermediate values (39.3 (7.1) pg/ml). Patients with acute myocardial infarction treated with intravenous streptokinase had normal concentrations of plasma atrial natriuretic peptide (20.2 (3.6) pg/mg), which were significantly lower than those in patients with myocardial infarction not given streptokinase. These changes could not be explained by factors such as age, pre-existing hypertension, renal dysfunction, or cardiac failure, nor treatment other than streptokinase. Raised plasma concentrations of atrial natriuretic peptide in acute myocardial infarction may be a homoeostatic response acting to reduce atrial pressures by natriuresis, diuresis, and venodilatation. The lower concentrations of atrial natriuretic peptide in patients with acute myocardial infarction treated with streptokinase may reflect a short term beneficial haemodynamic effect of streptokinase.
School/Discipline
Dissertation Note
Provenance
Description
Published Online First: 01 Sep 1989.
Access Status
Rights
Copyright status unknown