Plasma atrial natriuretic peptide in patients with acute myocardial infarction: effects of streptokinase

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dc.contributor.authorPhillips, P.
dc.contributor.authorSasadeus, J.
dc.contributor.authorHodsman, G.
dc.contributor.authorHorowitz, J.
dc.contributor.authorSaltups, A.
dc.contributor.authorJohnston, C.
dc.date.issued1989
dc.descriptionPublished Online First: 01 Sep 1989.
dc.description.abstractPlasma concentrations of immunoreactive atrial natriuretic peptide (mean (SEM] were measured in 135 patients admitted to two coronary care units with myocardial infarction, ischaemic chest pain, or non-ischaemic chest pain. Concentrations were significantly higher in patients with acute myocardial infarction not treated with systemic thrombolysis (60.4 (14.3) pg/ml) than in patients with non-ischaemic chest pain (21.1 (4.3) pg/ml). Patients with ischaemic chest pain had intermediate values (39.3 (7.1) pg/ml). Patients with acute myocardial infarction treated with intravenous streptokinase had normal concentrations of plasma atrial natriuretic peptide (20.2 (3.6) pg/mg), which were significantly lower than those in patients with myocardial infarction not given streptokinase. These changes could not be explained by factors such as age, pre-existing hypertension, renal dysfunction, or cardiac failure, nor treatment other than streptokinase. Raised plasma concentrations of atrial natriuretic peptide in acute myocardial infarction may be a homoeostatic response acting to reduce atrial pressures by natriuresis, diuresis, and venodilatation. The lower concentrations of atrial natriuretic peptide in patients with acute myocardial infarction treated with streptokinase may reflect a short term beneficial haemodynamic effect of streptokinase.
dc.description.statementofresponsibilityP A Phillips, J Sasadeus, G P Hodsman, J Horowitz, A Saltups, C I Johnston
dc.identifier.citationHeart, 1989; 61(2):139-143
dc.identifier.doi10.1136/hrt.61.2.139
dc.identifier.issn0007-0769
dc.identifier.issn1355-6037
dc.identifier.orcidPhillips, P. [0000-0002-9985-7631]
dc.identifier.orcidHorowitz, J. [0000-0001-6883-0703]
dc.identifier.urihttp://hdl.handle.net/2440/110935
dc.language.isoen
dc.publisherBMJ Publishing Group
dc.rightsCopyright status unknown
dc.source.urihttps://doi.org/10.1136/hrt.61.2.139
dc.subjectAtrial Natriuretic Factor
dc.titlePlasma atrial natriuretic peptide in patients with acute myocardial infarction: effects of streptokinase
dc.typeJournal article
pubs.publication-statusPublished

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