Adult cardiac-resident MSC-like stem cells with a proepicardial origin
Date
2011
Authors
Chong, J.J.H.
Chandrakanthan, V.
Xaymardan, M.
Asli, N.S.
Li, J.
Ahmed, I.
Heffernan, C.
Menon, M.K.
Scarlett, C.J.
Rashidianfar, A.
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Advisors
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Journal article
Citation
Cell Stem Cell, 2011; 9(6):527-540
Statement of Responsibility
James J.H. Chong, Vashe Chandrakanthan, Munira Xaymardan, Naisana S. Asli, Joan Li, Ishtiaq Ahmed, Corey Heffernan, Mary K. Menon, Christopher J. Scarlett, Amirsalar Rashidianfar, Christine Biben, Hans Zoellner, Emily K. Colvin, John E. Pimanda, Andrew V. Biankin, Bin Zhou, William T. Pu, Owen W.J. Prall, and Richard P. Harvey
Conference Name
Abstract
Colony-forming units – fibroblast (CFU-Fs), analogous to those giving rise to bone marrow (BM) mesenchymal stem cells (MSCs), are present in many organs, although the relationship between BM and organspecific CFU-Fs in homeostasis and tissue repair is unknown. Here we describe a population of adult cardiac-residentCFU-Fs (cCFU-Fs) that occupy a perivascular, adventitial niche and show broad trans-germ layer potency in vitro and in vivo. CRE lineage tracing and embryo analysis demonstrated a proepicardial origin for cCFU-Fs. Furthermore, inBMtransplantation chimeras, we found no interchange between BM and cCFU-Fs after aging, myocardial infarction, or BM stem cell mobilization. BM and cardiac and aortic CFU-Fs had distinctCRE lineage signatures, indicating that they arise from different progenitor beds during development. These diverse origins for CFU-Fs suggest an underlying basis for differentiation biases seen in different CFU-F populations, and could also influence their capacity for participating in tissue repair.
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© 2011 Elsevier Inc.