Adult cardiac-resident MSC-like stem cells with a proepicardial origin

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dc.contributor.authorChong, J.J.H.
dc.contributor.authorChandrakanthan, V.
dc.contributor.authorXaymardan, M.
dc.contributor.authorAsli, N.S.
dc.contributor.authorLi, J.
dc.contributor.authorAhmed, I.
dc.contributor.authorHeffernan, C.
dc.contributor.authorMenon, M.K.
dc.contributor.authorScarlett, C.J.
dc.contributor.authorRashidianfar, A.
dc.contributor.authorBiben, C.
dc.contributor.authorZoellner, H.
dc.contributor.authorColvin, E.K.
dc.contributor.authorPimanda, J.E.
dc.contributor.authorBiankin, A.V.
dc.contributor.authorZhou, B.
dc.contributor.authorPu, W.T.
dc.contributor.authorPrall, O.W.J.
dc.contributor.authorHarvey, R.P.
dc.date.issued2011
dc.description.abstractColony-forming units – fibroblast (CFU-Fs), analogous to those giving rise to bone marrow (BM) mesenchymal stem cells (MSCs), are present in many organs, although the relationship between BM and organspecific CFU-Fs in homeostasis and tissue repair is unknown. Here we describe a population of adult cardiac-residentCFU-Fs (cCFU-Fs) that occupy a perivascular, adventitial niche and show broad trans-germ layer potency in vitro and in vivo. CRE lineage tracing and embryo analysis demonstrated a proepicardial origin for cCFU-Fs. Furthermore, inBMtransplantation chimeras, we found no interchange between BM and cCFU-Fs after aging, myocardial infarction, or BM stem cell mobilization. BM and cardiac and aortic CFU-Fs had distinctCRE lineage signatures, indicating that they arise from different progenitor beds during development. These diverse origins for CFU-Fs suggest an underlying basis for differentiation biases seen in different CFU-F populations, and could also influence their capacity for participating in tissue repair.
dc.description.statementofresponsibilityJames J.H. Chong, Vashe Chandrakanthan, Munira Xaymardan, Naisana S. Asli, Joan Li, Ishtiaq Ahmed, Corey Heffernan, Mary K. Menon, Christopher J. Scarlett, Amirsalar Rashidianfar, Christine Biben, Hans Zoellner, Emily K. Colvin, John E. Pimanda, Andrew V. Biankin, Bin Zhou, William T. Pu, Owen W.J. Prall, and Richard P. Harvey
dc.identifier.citationCell Stem Cell, 2011; 9(6):527-540
dc.identifier.doi10.1016/j.stem.2011.10.002
dc.identifier.issn1934-5909
dc.identifier.issn1875-9777
dc.identifier.orcidChandrakanthan, V. [0000-0002-4314-5029]
dc.identifier.urihttps://hdl.handle.net/2440/145940
dc.language.isoen
dc.publisherCell Press; Elsevier
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/354400
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/573705
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/573707
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/535903
dc.rights© 2011 Elsevier Inc.
dc.source.urihttps://doi.org/10.1016/j.stem.2011.10.002
dc.subjectColony-forming units – fibroblast (CFU-Fs); bone marrow (BM); mesenchymal stem cells (MSCs); organs; homeostasis and tissue repair; adults; cardiac-residentCFU-Fs (cCFU-Fs); embryo; in vitro and in vivo
dc.subject.meshHeart
dc.subject.meshPericardium
dc.subject.meshBone Marrow Cells
dc.subject.meshCells, Cultured
dc.subject.meshFibroblasts
dc.subject.meshMyocytes, Cardiac
dc.subject.meshMesenchymal Stem Cells
dc.subject.meshAnimals
dc.subject.meshTransplantation Chimera
dc.subject.meshMice
dc.subject.meshColony-Forming Units Assay
dc.subject.meshCell Differentiation
dc.subject.meshCell Lineage
dc.subject.meshBiomarkers
dc.titleAdult cardiac-resident MSC-like stem cells with a proepicardial origin
dc.typeJournal article
pubs.publication-statusPublished

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